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FDA Complete Response Letters (CRLs)

Updated ·next FDA decision on the calendar

This page lists 47 Complete Response Letters covering January 2025 to June 2026. A Complete Response Letter means the FDA declined to approve the application as submitted, and it does not by itself mean the drug is rejected for good.

Not inferred from price. This page lists 47 decision(s) whose outcome was read from a document rather than from the share-price reaction. 18 of them link that document; the rest are older entries we have not yet gone back and sourced, and we would rather say so than call them all verified. A further 0 record(s) in our archive have their outcome inferred from the share-price reaction rather than read from a filing, and they are deliberately not listed under a heading that asserts what the FDA did. They remain in the full archive, labelled unverified. We published one such inference that turned out to be impossible; see corrections.
FDA Complete Response Letters with the reason, decision-day move and run-up. Labels under active validation; cross-check filings.
Browse: ✓ Approvals  ·  ✗ Complete Response Letters
2026 · 6
UNCY · 2026-06-30
CRL: Oxylanthanum Carbonate (OLC)
LNTH · 2026-06-26
CRL: LNTH-2501 (Gallium-68 edotreot
ACHV · 2026-06-22
CRL: Cytisinicline - (ORCA-3)
CING · 2026-06-02
CRL: CTx-1301 (fixed dose, pediatri
GRCE · 2026-04-23
CRL: GTX-104 - (STRIVE-ON)
ABBV · 2026-04-23
CRL: trenibotulinumtoxinE (Trenibot
REPL · 2026-04-10
CRL: RP1 (vusolimogene oderparepvec
INCY · 2026-04-08
CRL: ZYNYZ (retifanlimab-dlwr) - (P
MGNX · 2026-04-08
CRL: ZYNYZ (retifanlimab-dlwr) - (P
OTLK · 2026-04-07
CRL: LYTENAVA (bevacizumab-vikg) /
ALDX · 2026-03-17
CRL: Reproxalap (ADX-102) - (CHAMB
OTLK · 2026-03-05
CRL: LYTENAVA (bevacizumab-vikg) /
IRON · 2026-02-13
CRL: Bitopertin - (BEACON)
RGNX · 2026-02-09
CRL: clemidsogene lanparvovec (RGX-
UNCY · 2026-06-29 ✕
CRL: CRL for oxylanthanum carbonate (Jun 30 2026)
LNTH · 2026-06-29 ✕
CRL: CRL for LNTH-2501 (Ga-68 edotreotide) (Jun 2
ACHV · 2026-06-20 ✕
CRL: CRL for cytisinicline (Jun 22 2026)
IRON · 2026-02-15 ✗
CRL: price-only
RGNX · 2026-02-08 ✗
CRL: price-only
AQST · 2026-02-02 ✗
CRL: price-only
PHAR · 2026-02-01 ✗
CRL: source-verified
IBRX · 2026-01-16 ✗
CRL: source-verified
ATRA · 2026-01-12 ✗
CRL: price-only
2025 · 96
CORT · 2025-12-31 ✗
CRL: price-only
ENGN · 2025-11-11 ✗
CRL: source-verified
CYTK · 2025-11-07 ✗
CRL: price-only
ESLA · 2025-11-03 ✗
CRL: source-verified
ALVO · 2025-11-02 ✗
CRL: price-only
SNSE · 2025-10-17 ✗
CRL: source-verified
FBIO · 2025-10-01 ✗
CRL: price-only
OTLK · 2025-08-28 ✗
CRL: source-verified
PHIO · 2025-07-28 ✗
CRL: price-only
REPL · 2025-07-22 ✗
CRL: source-verified
CAPR · 2025-07-11 ✗
CRL: source-verified
JSPR · 2025-07-07 ✗
CRL: source-verified
UNCY · 2025-06-30 ✗
CRL: source-verified
TRAW · 2025-06-03 ✗
CRL: source-verified
SVRA · 2025-05-27 ✗
CRL: source-verified
URGN · 2025-04-27 ✗
CRL: price-only
ALDX · 2025-04-03 ✗
CRL: source-verified
MIST · 2025-03-28 ✗
CRL: source-verified
EQ · 2025-03-27 ✗
CRL: source-verified
ALLO · 2025-02-14 ✗
CRL: source-verified
LSTA · 2025-01-22 ✗
CRL: source-verified
ATRA · 2025-01-16 ✗
CRL: source-verified
PHIO · 2025-01-13 ✗
CRL: source-verified
JSPR · 2025-01-08 ✗
CRL: source-verified

Companies on this page

Every company listed above, with its full catalyst history, past FDA decisions and measured run-up into each one.
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