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UNCY FDA Decision CRL · 2025-06-30

Updated ·next FDA decision on the calendar
The FDA's own letter · Complete Response Letter, NDA 218607 (PDF), dated June 27, 2025, released under FDA's CRL transparency program. The company announced the decision on June 30, 2025; the FDA acted on June 27, 2025.
What the letter says has to be fixed (the letter's own section headings; read against the PDF, not openFDA's OCR text):
  • Facility inspections. Following a CGMP inspection and pre-approval inspection of a facility listed in the submission (name redacted), FDA conveyed deficiencies to the facility; satisfactory responses to the Form 483, and possibly CGMP re-inspection and an additional pre-approval inspection, are required before the application can be approved.
Labeling comment reserved until the application is otherwise adequate. The letter names no clinical efficacy or safety deficiency.
inspection CRL, OLC NDA CRL: third-party vendor cGMP inspection deficiency

Price into the decision (T-120)

PDUFA 6/30/25$9$4.611/13/25
Daily close, T-120 (1/13/25) through T+5. Run-up high $9 on 6/10/25, low $4.61 on 4/10/25 (T-120 to T-1). FDA decision 6/30/25. Historical price action, not a forecast.

Decision facts

FDA decision date2025-06-30
Outcome✗ CRL✓ source-verified
Decision-day move-29.9%
T-120 run-up (low→high)+57.0% ($4.6→$9.0)
CRL reasoninspection, OLC NDA CRL: third-party vendor cGMP inspection deficiency
Primary sourceView filing ↗
Market-cap tierMicro
Cohort decision-day move (history)4.6% median (n=308)

Cohort move is the historical median absolute decision-day move for this market-cap tier across our run-up study. History, not a prediction.

See the full 2026 PDUFA calendar →

Questions

Was source-verified approved by the FDA?

Not in this review cycle. On June 30, 2025 the FDA issued a Complete Response Letter, declining to approve the application for source-verified in its current form. A CRL is not final; the primary source is linked on this page.

How did UNCY stock react to the FDA decision?

On the decision day UNCY moved -29.9%. That is the recorded reaction to this specific event -- historical measurement, not a prediction, and not investment advice.