87 drugs lose patent protection in 2029. The biggest single group is Neurology & psychiatry, with 10 drugs. Losing protection does not mean a drug disappears: it means other manufacturers can apply to sell the same medicine, and the original maker usually loses most of the sales within a year or two.
This is the earliest date a generic could enter; it is not a guarantee one will. We calculate it as the later of the last patent the company listed with the FDA and the last regulatory exclusivity. Companies often reach settlement agreements with generic makers for a different date, and those agreements are not public in this data.
Lamictal XR (lamotrigine)Glaxosmithkline · 6 patents · January 7, 2029
Janumet (metformin hydrochloride; sitagliptin pho)Merck Sharp AND Dohme · 8 patents · January 21, 2029
Angiomax (bivalirudin)Sandoz · 4 patents · January 27, 2029
Lymphoseek KIT (technetium tc-99m tilmanocept)Cardinal Health 414 LLC Cardinal H · 1 patent · January 30, 2029
LO Loestrin FE (ethinyl estradiol; norethindrone acetate)Allergan Pharmaceuticals Internati · 1 patent · February 2, 2029
LO Minastrin FE (ethinyl estradiol; norethindrone acetate)Allergan Pharmaceuticals Internati · 1 patent · February 2, 2029
Actoplus MET (metformin hydrochloride; pioglitazone hy)Takeda Pharmaceuticals USA · 4 patents · February 3, 2029
Colcrys (colchicine)Takeda Pharmaceuticals USA · 17 patents · February 17, 2029
Vyzulta (latanoprostene bunod)Bausch AND Lomb · 1 patent · February 21, 2029
Dates from the FDA Orange Book, the official record of which patents cover
which approved drug; updated monthly. Facts only, not investment advice. Verify against the
Orange Book and primary filings. pdufa.bio is not affiliated with the FDA.
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